DNA ligase

BE0002622ProteinEnterococcus faecalis (strain ATCC 700802 / V583)ligA

DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is acted on by 5 drugs in DrugBank.

Gene name
ligA
UniProtKB entry
Q837V6Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
676 residues · 75,583 Da
Also known as
6.5.1.2 · Polydeoxyribonucleotide synthase [NAD(+)]

Resolves to

Protein
UniProtQ837V6UniProt nameDNLJ_ENTFA
Gene
NCBI Gene1199621
Pharmacology
KEGGefa:EF0722
Structure
PDB1TA8PDB1TAEPDB3BA8
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA ligase, and which indications are they being tested in?

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