DNA gyrase subunit B

BE0002665ProteinThermus thermophilusgyrB

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner (PubMed:11850422, PubMed:23804759). It is acted on by 1 drug in DrugBank.

Gene name
gyrB
UniProtKB entry
Q5SHZ4TrEMBL
Cellular location
Cytoplasmic
Residues / weight
634 residues · 70,537 Da
Also known as
5.6.2.2 · 5.99.1.3

Resolves to

Protein
UniProtQ5SHZ4UniProt nameGYRB_THET8
Structure
PDB1KIJ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on DNA gyrase subunit B, how selective are they, and which programs against it are still in active trials?

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