Metallo-beta-lactamase type 2

BE0002694ProteinChryseobacterium meningosepticumblaB1

Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. It is acted on by 1 drug in DrugBank.

Gene name
blaB1
UniProtKB entry
O08498Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
249 residues · 28,144 Da
Also known as
3.5.2.6 · B2 metallo-beta-lactamase · Beta-lactamase type II · blaB · Carbapenem-hydrolyzing beta-lactamase BlaB-1

Resolves to

Protein
UniProtO08498UniProt nameBLAB1_ELIME
Structure
PDB1M2X
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Metallo-beta-lactamase type 2, and which indications are they being tested in?

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