o-succinylbenzoate synthase

BE0002715ProteinEscherichia coli (strain K12)menC

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB) (PubMed:10194342, PubMed:8335646). It is acted on by 2 drugs in DrugBank.

Gene name
menC
UniProtKB entry
P29208Swiss-Prot
Residues / weight
320 residues · 35,476 Da
Also known as
4-(2'-carboxyphenyl)-4-oxybutyric acid synthase · 4.2.1.113 · o-succinylbenzoic acid synthase · OSB synthase

Resolves to

Protein
UniProtP29208UniProt nameMENC_ECOLI
Gene
NCBI Gene946734
Pharmacology
KEGGecj:JW2256
Structure
PDB1FHUPDB1FHVPDB1R6W
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on o-succinylbenzoate synthase, and which indications are they being tested in?

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