Kynureninase

Details

Name
Kynureninase
Kind
protein
Synonyms
  • 3.7.1.3
  • L-kynurenine hydrolase
Gene Name
kynU
UniProtKB Entry
P83788Swiss-Prot
Organism
Pseudomonas fluorescens
NCBI Taxonomy ID
294
Amino acid sequence
>lcl|BSEQ0011926|Kynureninase
MTTRNDCLALDAQDSLAPLRQQFALPEGVIYLDGNSLGARPVAALARAQAVIAEEWGNGL
IRSWNSAGWRDLSERLGNRLATLIGARDGEVVVTDTTSINLFKVLSAALRVQATRSPERR
VIVTETSNFPTDLYIAEGLADMLQQGYTLRLVDSPEELPQAIDQDTAVVMLTHVNYKTGY
MHDMQALTALSHECGALAIWDLAHSAGAVPVDLHQAGADYAIGCTYKYLNGGPGSQAFVW
VSPQLCDLVPQPLSGWFGHSRQFAMEPRYEPSNGIARYLCGTQPITSLAMVECGLDVFAQ
TDMASLRRKSLALTDLFIELVEQRCAAHELTLVTPREHAKRGSHVSFEHPEGYAVIQALI
DRGVIGDYREPRIMRFGFTPLYTTFTEVWDAVQILGEILDRKTWAQAQFQVRHSVT
Number of residues
416
Molecular Weight
45904.725
Theoretical pI
5.25
GO Classification
Functions
kynureninase activity / pyridoxal phosphate binding
Processes
'de novo' NAD biosynthetic process from tryptophan / anthranilate metabolic process / L-kynurenine catabolic process / quinolinate biosynthetic process / tryptophan catabolic process
Components
cytoplasm
General Function
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.
Specific Function
3-hydroxykynureninase activity
Pfam Domain Function
Not Available
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP83788
UniProtKB Entry NameKYNU_PSEFL
PDB ID(s)1QZ9
General References
  1. Momany C, Levdikov V, Blagova L, Lima S, Phillips RS: Three-dimensional structure of kynureninase from Pseudomonas fluorescens. Biochemistry. 2004 Feb 10;43(5):1193-203. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
3,6,9,12,15-PentaoxaheptadecaneexperimentalunknowntargetDetails