HTH-type transcriptional regulator EthR

BE0002743ProteinMycobacterium tuberculosisethR

Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH). It is acted on by 4 drugs in DrugBank.

Gene name
ethR
UniProtKB entry
P9WMC1Swiss-Prot
Residues / weight
216 residues · 23,756 Da
Also known as
etaR

Resolves to

Protein
UniProtP9WMC1UniProt nameETHR_MYCTU
Gene
NCBI Gene886189
Pharmacology
KEGGmtu:Rv3855
Structure
PDB1T56PDB1U9NPDB1U9O
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on HTH-type transcriptional regulator EthR, and which indications are they being tested in?

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