ATP-dependent Clp protease proteolytic subunit, mitochondrial

BE0002769ProteinHumansCLPP

Protease component of the ClpXP complex that cleaves peptides and various proteins in an ATP-dependent process. It is acted on by 2 drugs in DrugBank.

Gene name
CLPP
UniProtKB entry
Q16740Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
277 residues · 30,180 Da
Also known as
3.4.21.92 · Caseinolytic mitochondrial matrix peptidase proteolytic subunit · Endopeptidase Clp

Resolves to

Protein
UniProtQ16740UniProt nameCLPP_HUMAN
Gene
HGNCHGNC:2084NCBI Gene8192GeneCardsCLPP
Pharmacology
IUPHAR/GtoPdb3273KEGGhsa:8192
Structure
PDB1TG6PDB6BBAPDB6DL7
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ATP-dependent Clp protease proteolytic subunit, mitochondrial, how selective are they, and which programs against it are still in active trials?

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