Holliday junction branch migration complex subunit RuvB

BE0002792ProteinThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)ruvB

The RuvA-RuvB-RuvC complex processes Holliday junction (HJ) DNA during genetic recombination and DNA repair, while the RuvA-RuvB complex plays an important role in the rescue of blocked DNA replication forks via replication fork reversal (RFR). It is acted on by 1 drug in DrugBank.

Gene name
ruvB
UniProtKB entry
Q5SL87Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
324 residues · 35,973 Da
Also known as
3.6.4.- · 3.6.4.12 · Holliday junction ATP-dependent DNA helicase RuvB

Resolves to

Protein
UniProtQ5SL87UniProt nameRUVB_THET8
Gene
NCBI Gene3168960
Pharmacology
KEGGttj:TTHA0406
Structure
PDB1HQCPDB1IXRPDB1IXS
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Holliday junction branch migration complex subunit RuvB, how selective are they, and which programs against it are still in active trials?

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