Peptide deformylase
Details
- Name
- Peptide deformylase
- Kind
- protein
- Synonyms
- 3.5.1.88
- Gene Name
- Not Available
- UniProtKB Entry
- Q8I372TrEMBL
- Organism
- Plasmodium falciparum (isolate 3D7)
- NCBI Taxonomy ID
- 36329
- Amino acid sequence
>lcl|BSEQ0022036|Peptide deformylase MLMYYSLFLFNLIICCNVTSIYGYIHNVRSLEPYIKNDQIKNYSSNIKQKRKGSLYLLKN EKDEIKIVKYPDPILRRRSEEVTNFDDNLKRVVRKMFDIMYESKGIGLSAPQVNISKRII VWNALYEKRKEENERIFINPSIVEQSLVKLKLIEGCLSFPGIEGKVERPSIVSISYYDIN GYKHLKILKGIHSRIFQHEFDHLNGTLFIDKMTQVDKKKVRPKLNELIRDYKATHSEEPA L
- Number of residues
- 241
- Molecular Weight
- 28393.87
- Theoretical pI
- 9.88
- GO Classification
- Functionsferrous iron binding / peptide deformylase activityProcessesco-translational protein modification / N-terminal protein amino acid modification / translationComponentsapicoplast / integral component of membrane
- General Function
- Removes the formyl group from the N-terminal Met of newly synthesized proteins.
- Specific Function
- ferrous iron binding
- Pfam Domain Function
- Pep_deformylase (PF01327)
- Signal Regions
- Not Available
- Transmembrane Regions
- 6-25
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0022037|Peptide deformylase ATGTTGATGTATTATTCACTTTTCCTTTTTAATTTAATAATATGTTGTAATGTTACAAGT ATTTATGGATATATACACAATGTTAGATCACTTGAACCATATATAAAAAATGATCAGATA AAAAATTATAGTAGTAATATAAAACAAAAGAGAAAAGGCTCTTTATATTTATTAAAAAAT GAAAAGGATGAGATAAAAATCGTCAAGTACCCGGACCCTATATTAAGGCGACGAAGTGAA GAAGTCACAAATTTTGATGATAATTTGAAGAGAGTTGTGAGAAAAATGTTTGATATTATG TACGAGAGCAAAGGTATTGGTTTGTCTGCACCACAAGTAAATATAAGCAAACGAATTATT GTATGGAATGCATTATATGAAAAAAGAAAAGAAGAAAATGAACGAATATTTATTAATCCG TCCATAGTAGAACAGAGTCTAGTTAAATTAAAATTAATAGAAGGATGTTTATCATTTCCT GGAATAGAAGGAAAAGTTGAACGACCTAGTATAGTATCTATATCATATTATGATATTAAT GGATATAAACATTTAAAAATTTTGAAAGGTATACATTCTAGAATATTTCAACATGAATTT GATCATCTTAATGGTACATTATTTATTGATAAAATGACACAAGTCGATAAAAAAAAAGTA AGACCAAAACTTAACGAGCTAATTAGGGATTATAAGGCTACTCACTCAGAAGAACCAGCC CTATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8I372 UniProtKB Entry Name Q8I372_PLAF7 GenBank Gene ID AL929356 PDB ID(s) 1JYM, 1RL4, 1RQC KEGG ID pfa:PFI0380c NCBI Gene ID 813356 - General References
- Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
- Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, Barron A, Brooks K, Buckee CO, Burrows C, Cherevach I, Chillingworth C, Chillingworth T, Christodoulou Z, Clark L, Clark R, Corton C, Cronin A, Davies R, Davis P, Dear P, Dearden F, Doggett J, Feltwell T, Goble A, Goodhead I, Gwilliam R, Hamlin N, Hance Z, Harper D, Hauser H, Hornsby T, Holroyd S, Horrocks P, Humphray S, Jagels K, James KD, Johnson D, Kerhornou A, Knights A, Konfortov B, Kyes S, Larke N, Lawson D, Lennard N, Line A, Maddison M, McLean J, Mooney P, Moule S, Murphy L, Oliver K, Ormond D, Price C, Quail MA, Rabbinowitsch E, Rajandream MA, Rutter S, Rutherford KM, Sanders M, Simmonds M, Seeger K, Sharp S, Smith R, Squares R, Squares S, Stevens K, Taylor K, Tivey A, Unwin L, Whitehead S, Woodward J, Sulston JE, Craig A, Newbold C, Barrell BG: Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Nature. 2002 Oct 3;419(6906):527-31. [Article]
- Kumar A, Nguyen KT, Srivathsan S, Ornstein B, Turley S, Hirsh I, Pei D, Hol WG: Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design. Structure. 2002 Mar;10(3):357-67. [Article]
- Robien MA, Nguyen KT, Kumar A, Hirsh I, Turley S, Pei D, Hol WG: An improved crystal form of Plasmodium falciparum peptide deformylase. Protein Sci. 2004 Apr;13(4):1155-63. Epub 2004 Mar 9. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details (2r)-2-{[Formyl(Hydroxy)Amino]Methyl}Hexanoic Acid experimental unknown target Details (2S,2'S)-2,2'-(1,2-Hydrazinediylbis{methylene[(2S)-1-oxo-2,1-hexanediyl]imino})bis(6-amino-N-phenylhexanamide) experimental unknown target Details