Envelope glycoprotein gp160
Details
- Name
- Envelope glycoprotein gp160
- Kind
- protein
- Synonyms
- Env polyprotein
- Gene Name
- env
- UniProtKB Entry
- P05884Swiss-Prot
- Organism
- SIV-mac
- NCBI Taxonomy ID
- 11735
- Amino acid sequence
>lcl|BSEQ0005515|Envelope glycoprotein gp160 MGCLGNQLLIAILLLSVYGIYCTQYVTVFYGVPAWRNATIPLFCATKNRDTWGTTQCLPD NGDYSELALNVTESFDAWENTVTEQAIEDVWQLFETSIKPCVKLSPLCITMRCNKSETDR WGLTKSSTTITTAAPTSAPVSEKIDMVNETSSCIAQNNCTGLEQEQMISCKFTMTGLKRD KTKEYNETWYSTDLVCEQGNSTDNESRCYMNHCNTSVIQESCDKHYWDTIRFRYCAPPGY ALLRCNDTNYSGFMPKCSKVVVSSCTRMMETQTSTWFGFNGTRAENRTYIYWHGRDNRTI ISLNKYYNLTMKCRRPGNKTVLPVTIMSGLVFHSQPLTDRPKQAWCWFGGKWKDAIKEVK QTIVKHPRYTGTNNTDKINLTAPGGGDPEVTFMWTNCRGEFLYCKMNWFLNWVEDRDVTT QRPKERHRRNYVPCHIRQIINTWHKVGKNVYLPPREGDLTCNSTVTSLIANIDWTDGNQT SITMSAEVAELYRLELGDYKLVEITPIGLAPTDVKRYTTGGTSRNKRGVFVLGFLGFLAT AGSAMGAASFRLTAQSRTLLAGIVQQQQQLLGVVKRQQELLRLTVWGTKNLQTRVTAIEK YLEDQAQLNAWGCAFRQVCHTTVPWPNASLTPDWNNDTWQEWERKVDFLEENITALLEEA QIQQEKNMYELQKLNSWDVFGNWFDLASWIKYIQYGIYVVVGVILLRIVIYIVQMLAKLR QGYRPVFSSPPSYFQXTHTQQDPALPTREGKEGDGGEGGGNSSWPWQIEYIHFLIRQLIR LLTWLFSNCRTLLSRAYQILQPILQRLSATLRRIREVLRTELTYLQYGWSYFHEAVQAGW RSATETLAGAWGDLWETLRRGGRWILAIPRRIRQGLELTLL
- Number of residues
- 881
- Molecular Weight
- Not Available
- Theoretical pI
- 8.4
- GO Classification
- Functionsstructural molecule activityProcessesmembrane fusion involved in viral entry into host cell / virion attachment to host cellComponentshost cell endosome membrane / host cell plasma membrane / integral component of membrane / viral envelope / virion membrane
- General Function
- The surface protein gp120 (SU) attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. This interaction induces a structural rearrangement creating a high affinity binding site for a chemokine coreceptor like CCR5. This peculiar 2 stage receptor-interaction strategy allows gp120 to maintain the highly conserved coreceptor-binding site in a cryptic conformation, protected from neutralizing antibodies. These changes are transmitted to the transmembrane protein gp41 and are thought to activate its fusogenic potential by unmasking its fusion peptide (By similarity).
- Specific Function
- structural molecule activity
- Pfam Domain Function
- Signal Regions
- 1-19
- Transmembrane Regions
- 697-717
- Cellular Location
- Virion membrane
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P05884 UniProtKB Entry Name ENV_SIVMK PDB ID(s) 2BF1 - General References
- Franchini G, Gurgo C, Guo HG, Gallo RC, Collalti E, Fargnoli KA, Hall LF, Wong-Staal F, Reitz MS Jr: Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses. Nature. 1987 Aug 6-12;328(6130):539-43. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details N-acetyl-alpha-D-glucosamine experimental unknown target Details alpha-L-fucose experimental unknown target Details