dTDP-epi-vancosaminyltransferase

BE0002817ProteinAmycolatopsis orientalisgtfA

Catalyzes the attachment of 4-epi-vancosamine from a TDP donor to the beta-OH-Tyr-6 of the aglycone cosubstrate in the biosynthesis of glycopeptide antibiotic chloroeremomycin, a member of the vancomycin group of antibiotics. It is acted on by 1 drug in DrugBank.

Gene name
gtfA
UniProtKB entry
P96558Swiss-Prot
Residues / weight
396 residues · 41,662 Da
Also known as
2.4.1.311 · Glycosyltransferase AH1 · Glycosyltransferase GtfA · GtfAH1

Resolves to

Protein
UniProtP96558UniProt nameGTFA_AMYOR
Pharmacology
KEGGag:CAA11774
Structure
PDB1PN3PDB1PNVPDB3H4I
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
3GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on dTDP-epi-vancosaminyltransferase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In