Diadenosine hexaphosphate hydrolase
Details
- Name
- Diadenosine hexaphosphate hydrolase
- Kind
- protein
- Synonyms
- 3.6.1.61
- Ap6A hydrolase
- ATP-generating (di)nucleotide polyphosphate hydrolase
- ATP-generating Ap6A hydrolase
- Nudix protein
- Gene Name
- ndx1
- UniProtKB Entry
- Q75UV1Swiss-Prot
- Organism
- Thermus thermophilus
- NCBI Taxonomy ID
- 274
- Amino acid sequence
>lcl|BSEQ0011987|Diadenosine hexaphosphate hydrolase MELGAGGVVFNAKREVLLLRDRMGFWVFPKGHPEPGESLEEAAVREVWEETGVRAEVLLP LYPTRYVNPKGVEREVHWFLMRGEGAPRLEEGMTGAGWFSPEEARALLAFPEDLGLLEVA LERLPL
- Number of residues
- 126
- Molecular Weight
- 14170.205
- Theoretical pI
- 4.52
- GO Classification
- FunctionsATP binding / hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / metal ion binding
- General Function
- Specifically hydrolyzes (di)adenosine polyphosphates but not ATP or diadenosine triphosphate, generating ATP as the product. Diadenosine hexaphosphate (Ap6A) is the preferred substrate and hydrolysis yields 2 ATP. It is the only enzyme that symmetrically hydrolyzes Ap6A. It also hydrolyzes diadenosine pentaphosphate (Ap5A), diadenosine tetraphosphate (Ap4A) and adenosine tetraphosphate (p4A).
- Specific Function
- ATP binding
- Pfam Domain Function
- Not Available
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011988|Diadenosine hexaphosphate hydrolase (ndx1) ATGGAGCTAGGGGCCGGGGGCGTGGTCTTCAACGCCAAACGGGAGGTCCTCCTCCTTCGC GACCGCATGGGCTTCTGGGTCTTCCCCAAGGGCCACCCGGAGCCGGGGGAGAGCCTGGAG GAGGCGGCGGTGCGGGAGGTCTGGGAGGAGACGGGGGTCCGGGCCGAGGTCCTCCTTCCC CTCTACCCCACCCGCTACGTCAACCCCAAGGGGGTAGAGCGGGAGGTGCACTGGTTCCTC ATGCGGGGGGAGGGGGCGCCCCGCCTGGAGGAGGGCATGACCGGGGCGGGGTGGTTTTCC CCCGAGGAGGCCCGCGCCCTCCTCGCCTTCCCCGAGGACCTGGGGCTTTTGGAGGTGGCC CTTGAGCGTCTACCGCTTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q75UV1 UniProtKB Entry Name NDX1_THETH GenBank Gene ID AB125632 PDB ID(s) 1VC8, 1VC9, 1VCD KEGG ID ttj:TTHA1880 NCBI Gene ID 3169127 - General References
- Iwai T, Kuramitsu S, Masui R: The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity. J Biol Chem. 2004 May 21;279(21):21732-9. Epub 2004 Mar 15. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Adenosine-5'-Pentaphosphate experimental unknown target Details