Hydroxylamine reductase
Details
- Name
- Hydroxylamine reductase
- Kind
- protein
- Synonyms
- 1.7.99.1
- HCP
- Hybrid-cluster protein
- Prismane protein
- Gene Name
- hcp
- UniProtKB Entry
- P31101Swiss-Prot
- Organism
- Desulfovibrio vulgaris (strain Hildenborough / ATCC 29579 / NCIMB 8303)
- NCBI Taxonomy ID
- 882
- Amino acid sequence
>lcl|BSEQ0016902|Hydroxylamine reductase MFCFQCQETAKNTGCTVKGMCGKPEETANLQDLLIFVLRGIAIYGEKLKELGQPDRSNDD FVLQGLFATITNANWDDARFEAMISEGLARRDKLRNAFLAVYKAKNGKDFSEPLPEAATW TGDSTAFAEKAKSVGILATENEDVRSLRELLIIGLKGVAAYAEHAAVLGFRKTEIDEFML EALASTTKDLSVDEMVALVMKAGGMAVTTMALLDEANTTTYGNPEITQVNIGVGKNPGIL ISGHDLKDMAELLKQTEGTGVDVYTHGEMLPANYYPAFKKYPHFVGNYGGSWWQQNPEFE SFNGPILLTTNCLVPLKKENTYLDRLYTTGVVGYEGAKHIADRPAGGAKDFSALIAQAKK CPPPVEIETGSIVGGFAHHQVLALADKVVEAVKSGAIKRFVVMAGCDGRQKSRSYYTEVA ENLPKDTVILTAGCAKYRYNKLNLGDIGGIPRVLDAGQCNDSYSLAVIALKLKEVFGLDD INDLPVSYDIAWYEQKAVAVLLALLFLGVKGIRLGPTLPAFLSPNVAKVLVENFNIKPIG TVQDDIAAMMAGK
- Number of residues
- 553
- Molecular Weight
- 59978.4
- Theoretical pI
- 5.29
- GO Classification
- Functions4 iron, 4 sulfur cluster binding / hydroxylamine reductase activity / metal ion bindingComponentscytoplasm
- General Function
- Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
- Specific Function
- 4 iron, 4 sulfur cluster binding
- Pfam Domain Function
- Prismane (PF03063)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016903|Hydroxylamine reductase (hcp) ATGTTTTGCTTCCAGTGTCAGGAAACAGCGAAGAATACGGGATGCACGGTCAAAGGTATG TGCGGCAAGCCGGAAGAAACCGCCAATTTGCAGGATCTGCTCATTTTTGTGCTGCGTGGC ATCGCCATTTATGGCGAAAAATTAAAGGAGTTGGGACAGCCGGACCGCTCTAATGACGAC TTCGTGCTCCAGGGATTATTTGCGACCATCACCAATGCTAACTGGGATGATGCCCGATTT GAGGCTATGATATCGGAAGGCTTGGCTCGGCGTGACAAGTTGAGAAATGCTTTTCTGGCT GTTTACAAGGCAAAAAATGGCAAAGATTTCAGCGAGCCGTTGCCCGAAGCCGCGACTTGG ACTGGGGACTCTACCGCTTTTGCTGAAAAGGCCAAGAGCGTAGGCATTCTGGCAACTGAG AACGAAGATGTGCGTTCTTTGCGCGAACTGCTCATAATCGGTCTGAAAGGTGTCGCGGCC TATGCCGAGCACGCTGCTGTACTGGGCTTTCGCAAGACCGAAATCGACGAATTCATGCTT GAGGCCCTGGCTTCAACGACCAAGGATTTGTCCGTGGATGAAATGGTCGCGCTGGTCATG AAGGCCGGCGGCATGGCCGTAACCACCATGGCCCTGCTGGACGAGGCCAACACCACTACC TACGGCAACCCGGAAATCACCCAGGTCAACATCGGCGTGGGCAAGAACCCCGGCATCCTC ATCAGCGGCCATGACCTGAAGGATATGGCCGAGTTGCTGAAGCAGACCGAGGGCACAGGC GTGGACGTTTACACCCACGGCGAAATGCTTCCCGCCAACTATTATCCGGCGTTCAAGAAG TACCCGCATTTCGTGGGGAACTACGGCGGTTCCTGGTGGCAGCAGAATCCCGAATTCGAG TCCTTCAACGGCCCCATCCTGCTGACCACAAACTGTCTGGTGCCGCTCAAAAAAGAGAAC ACCTATCTGGACCGTCTCTACACCACTGGCGTGGTTGGGTATGAAGGGGCCAAGCACATC GCTGACCGGCCTGCGGGAGGAGCCAAGGATTTCTCGGCGCTGATCGCACAGGCCAAGAAA TGTCCTCCGCCCGTTGAGATCGAGACTGGTAGCATCGTCGGCGGTTTCGCCCATCATCAG GTACTAGCCTTGGCCGACAAGGTGGTTGAGGCTGTCAAGTCCGGCGCGATCAAGCGCTTT GTGGTCATGGCCGGGTGTGACGGTCGGCAGAAGTCTCGTTCCTATTACACTGAAGTGGCC GAAAATTTGCCCAAGGACACCGTGATCTTGACGGCCGGTTGCGCCAAGTACCGCTATAAC AAACTGAATCTCGGTGACATCGGTGGCATTCCACGTGTGCTGGACGCAGGGCAGTGCAAC GATTCCTATTCCCTGGCCGTCATTGCTCTGAAACTCAAAGAAGTCTTCGGCCTGGATGAC ATCAACGATCTGCCCGTATCTTACGATATCGCCTGGTACGAGCAGAAGGCCGTGGCCGTG CTTCTGGCCCTCCTATTCTTAGGTGTGAAGGGAATCCGCCTCGGACCCACGCTTCCGGCA TTCCTGTCCCCGAACGTGGCCAAGGTACTGGTTGAAAATTTCAACATCAAACCAATCGGA ACAGTGCAGGATGACATCGCGGCCATGATGGCGGGTAAATAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P31101 UniProtKB Entry Name HCP_DESVH GenBank Gene ID Z11707 PDB ID(s) 1E1D, 1E2U, 1E9V, 1GNT, 1OA1, 1W9M KEGG ID dvu:DVU2013 NCBI Gene ID 2796735 - General References
- Stokkermans JP, Pierik AJ, Wolbert RB, Hagen WR, Van Dongen WM, Veeger C: The primary structure of a protein containing a putative [6Fe-6S] prismane cluster from Desulfovibrio vulgaris (Hildenborough). Eur J Biochem. 1992 Sep 1;208(2):435-42. [Article]
- Heidelberg JF, Seshadri R, Haveman SA, Hemme CL, Paulsen IT, Kolonay JF, Eisen JA, Ward N, Methe B, Brinkac LM, Daugherty SC, Deboy RT, Dodson RJ, Durkin AS, Madupu R, Nelson WC, Sullivan SA, Fouts D, Haft DH, Selengut J, Peterson JD, Davidsen TM, Zafar N, Zhou L, Radune D, Dimitrov G, Hance M, Tran K, Khouri H, Gill J, Utterback TR, Feldblyum TV, Wall JD, Voordouw G, Fraser CM: The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough. Nat Biotechnol. 2004 May;22(5):554-9. Epub 2004 Apr 11. [Article]
- Pierik AJ, Wolbert RB, Mutsaers PH, Hagen WR, Veeger C: Purification and biochemical characterization of a putative [6Fe-6S] prismane-cluster-containing protein from Desulfovibrio vulgaris (Hildenborough). Eur J Biochem. 1992 Jun 15;206(3):697-704. [Article]
- Pierik AJ, Hagen WR, Dunham WR, Sands RH: Multi-frequency EPR and high-resolution Mossbauer spectroscopy of a putative [6Fe-6S] prismane-cluster-containing protein from Desulfovibrio vulgaris (Hildenborough). Characterization of a supercluster and superspin model protein. Eur J Biochem. 1992 Jun 15;206(3):705-19. [Article]
- Krockel M, Trautwein AX, Arendsen AF, Hagen WR: The prismane protein resolved--Mossbauer investigation of a 4Fe cluster with an unusual mixture of bridging ligands and metal coordinations. Eur J Biochem. 1998 Jan 15;251(1-2):454-61. [Article]
- Cooper SJ, Garner CD, Hagen WR, Lindley PF, Bailey S: Hybrid-cluster protein (HCP) from Desulfovibrio vulgaris (Hildenborough) at 1.6 A resolution. Biochemistry. 2000 Dec 12;39(49):15044-54. [Article]
- Macedo S, Mitchell EP, Romao CV, Cooper SJ, Coelho R, Liu MY, Xavier AV, LeGall J, Bailey S, Garner DC, Hagen WR, Teixeira M, Carrondo MA, Lindley P: Hybrid cluster proteins (HCPs) from Desulfovibrio desulfuricans ATCC 27774 and Desulfovibrio vulgaris (Hildenborough): X-ray structures at 1.25 A resolution using synchrotron radiation. J Biol Inorg Chem. 2002 Apr;7(4-5):514-25. Epub 2002 Jan 23. [Article]
- Aragao D, Macedo S, Mitchell EP, Romao CV, Liu MY, Frazao C, Saraiva LM, Xavier AV, LeGall J, van Dongen WM, Hagen WR, Teixeira M, Carrondo MA, Lindley P: Reduced hybrid cluster proteins (HCP) from Desulfovibrio desulfuricans ATCC 27774 and Desulfovibrio vulgaris (Hildenborough): X-ray structures at high resolution using synchrotron radiation. J Biol Inorg Chem. 2003 May;8(5):540-8. Epub 2003 Feb 15. [Article]
- Aragao D, Mitchell EP, Frazao CF, Carrondo MA, Lindley PF: Structural and functional relationships in the hybrid cluster protein family: structure of the anaerobically purified hybrid cluster protein from Desulfovibrio vulgaris at 1.35 A resolution. Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):665-74. doi: 10.1107/S0907444908009165. Epub 2008 May 14. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details S-Mercaptocysteine experimental unknown target Details