Estradiol 17-beta-dehydrogenase 11

BE0002840ProteinHumansHSD17B11

Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. It is acted on by 1 drug in DrugBank.

Gene name
HSD17B11
UniProtKB entry
Q8NBQ5Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
300 residues · 32,964 Da
Also known as
1.1.1.62 · 17-beta-HSD 11 · 17-beta-HSD XI · 17-beta-hydroxysteroid dehydrogenase 11 · 17-beta-hydroxysteroid dehydrogenase XI

Resolves to

Protein
UniProtQ8NBQ5UniProt nameDHB11_HUMAN
Gene
HGNCHGNC:22960NCBI Gene51170GeneCardsHSD17B11
Pharmacology
KEGGhsa:51170
Structure
PDB1YB1
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Estradiol 17-beta-dehydrogenase 11, and which indications are they being tested in?

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