(5R)-carbapenem-3-carboxylate synthase

BE0002848ProteinPectobacterium carotovorum subsp. carotovorumcarC

Catalyzes the Fe(2+) and alpha-ketoglutarate-dependent conversion of (3S,5S)-carbapenam to (5R)-carbapenem, an essential step in carbapenem antibiotic biosynthesis. It is acted on by 1 drug in DrugBank.

Gene name
carC
UniProtKB entry
Q9XB59Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
273 residues · 31,611 Da
Also known as
1.14.20.3 · Carbapenem synthase

Resolves to

Protein
UniProtQ9XB59UniProt nameCARC_PECCC
Structure
PDB1NX4PDB1NX8PDB4OJ8
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
4GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
4+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on (5R)-carbapenem-3-carboxylate synthase, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In