Mismatch repair endonuclease PMS2

BE0002851ProteinHumansPMS2

Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). It is acted on by 1 drug in DrugBank.

Gene name
PMS2
UniProtKB entry
P54278Swiss-Prot
Cellular location
Nucleus
Residues / weight
862 residues · 95,796 Da
Also known as
3.1.-.- · DNA mismatch repair protein PMS2 · PMS1 protein homolog 2 · PMSL2

Resolves to

Protein
UniProtP54278UniProt namePMS2_HUMAN
Gene
HGNCHGNC:9122NCBI Gene5395GeneCardsPMS2
Pharmacology
KEGGhsa:5395
Structure
PDB1EA6PDB1H7SPDB1H7U
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Mismatch repair endonuclease PMS2, and which indications are they being tested in?

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