DNA polymerase III subunit tau

BE0002852ProteinEscherichia coli (strain K12)dnaX

Part of the beta sliding clamp loading complex, which hydrolyzes ATP to load the beta clamp onto primed DNA to form the DNA replication pre-initiation complex (PubMed:2040637). It is acted on by 1 drug in DrugBank.

Gene name
dnaX
UniProtKB entry
P06710Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
643 residues · 71,137 Da
Also known as
2.7.7.7 · DNA polymerase III subunit gamma · dnaZ · dnaZX

Resolves to

Protein
UniProtP06710UniProt nameDPO3X_ECOLI
Gene
NCBI Gene945105
Pharmacology
KEGGecj:JW0459
Structure
PDB1JR3PDB1NJFPDB1NJG
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA polymerase III subunit tau, and which indications are they being tested in?

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