Catalase-peroxidase
Details
- Name
- Catalase-peroxidase
- Kind
- protein
- Synonyms
- 1.11.1.21
- CP
- Peroxidase/catalase
- Gene Name
- katG
- UniProtKB Entry
- Q939D2Swiss-Prot
- Organism
- Burkholderia pseudomallei (strain K96243)
- NCBI Taxonomy ID
- 272560
- Amino acid sequence
>lcl|BSEQ0037216|Catalase-peroxidase MSNEAKCPFHQAAGNGTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAV KRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWP DNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDV YWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDT FARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGAD AITSGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKK HRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVP AEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGA NGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVE QAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDK AQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAA DADVFEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVM NLDRFDLA
- Number of residues
- 728
- Molecular Weight
- 79445.485
- Theoretical pI
- 6.25
- GO Classification
- Functionscatalase activity / heme binding / metal ion bindingProcesseshydrogen peroxide catabolic process / response to oxidative stress
- General Function
- Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Also displays NADH oxidase, isoniazid hydrazine lyase and isonicotinoyl-NAD synthase activities.
- Specific Function
- catalase activity
- Pfam Domain Function
- peroxidase (PF00141)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016918|Catalase-peroxidase (katG) ATGCCCGGCTCCGATGCCGGGCCCCGCAGGCGGGGCGTACACGAACAAAGGAGAAATCGC ATGTCGAATGAAGCGAAGTGCCCGTTCCATCAAGCCGCAGGCAACGGCACGTCGAACCGG GACTGGTGGCCCAATCAGCTGGACCTGAGCATCCTGCATCGGCACTCGTCGCTGTCCGAT CCGATGGGCAAGGATTTCAACTACGCGCAGGCGTTCGAGAAGCTCGACCTCGCGGCGGTG AAGCGCGACCTCCACGCGCTGATGACGACGTCGCAGGACTGGTGGCCGGCCGATTTCGGC CACTACGGCGGCCTGTTCATCCGCATGGCATGGCACAGCGCGGGCACGTACCGCACGGCC GACGGCCGCGGCGGCGCGGGCGAAGGGCAGCAGCGCTTCGCGCCGCTCAACAGCTGGCCC GACAACGCGAACCTCGACAAGGCGCGCCGGCTGCTGTGGCCGATCAAGCAGAAGTACGGC CGCGCCATCTCGTGGGCCGACCTGCTGATCCTGACGGGCAACGTCGCGCTCGAATCGATG GGCTTCAAGACCTTCGGCTTCGCGGGCGGCCGCGCGGACACGTGGGAGCCCGAGGACGTC TACTGGGGCTCGGAAAAGATCTGGCTGGAACTGAGCGGCGGCCCGAACAGCCGCTATTCG GGCGACCGCCAGCTCGAGAACCCGCTCGCCGCCGTGCAGATGGGCCTCATCTACGTGAAT CCGGAAGGCCCGGACGGCAATCCCGATCCGGTCGCCGCGGCGCGCGACATTCGTGACACC TTCGCGCGCATGGCGATGAACGACGAAGAGACGGTCGCGCTGATCGCGGGCGGCCACACG TTCGGCAAGACGCACGGCGCGGGGCCCGCGTCGAACGTCGGCGCCGAGCCGGAGGCCGCG GGCATCGAAGCGCAGGGCCTCGGCTGGAAGAGCGCGTACCGCACGGGCAAGGGCGCGGAC GCGATCACGAGCGGGCTCGAAGTCACGTGGACGACGACGCCGACGCAGTGGAGCCACAAC TTCTTCGAGAACCTGTTCGGCTACGAGTGGGAACTGACGAAGAGCCCGGCGGGCGCGCAC CAGTGGGTCGCGAAGGGCGCCGACGCGGTGATTCCCGACGCGTTCGATCCGTCGAAGAAG CATCGTCCGACGATGCTCACGACCGACCTGTCGCTGCGCTTCGATCCGGCGTACGAAAAG ATCTCGCGCCGCTTCCACGAGAACCCGGAGCAGTTCGCCGACGCGTTCGCGCGCGCCTGG TTCAAGCTCACGCACCGCGACATGGGCCCGCGCGCGCGCTATCTCGGCCCGGAAGTGCCG GCCGAGGTGCTGCTGTGGCAGGACCCGATTCCGGCCGTCGACCATCCGCTGATCGACGCC GCGGACGCCGCCGAGCTGAAGGCAAAGGTGCTCGCGTCGGGGCTGACCGTGTCGCAGCTC GTTTCCACCGCGTGGGCGGCGGCGTCCACCTTCCGCGGCTCGGACAAGCGCGGCGGCGCG AACGGCGCGCGCATTCGCCTTGCGCCGCAGAAGGACTGGGAGGCGAACCAGCCCGAGCAG CTCGCGGCGGTGCTCGAGACGCTCGAGGCAATCCGCACGGCGTTCAACGGCGCGCAGCGC GGCGGCAAGCAAGTGTCGCTCGCCGATCTGATCGTGCTGGCCGGCTGCGCGGGCGTCGAG CAGGCGGCGAAGAACGCGGGCCACGCGGTGACCGTGCCGTTCGCGCCGGGCCGCGCGGAC GCATCGCAGGAGCAGACCGACGTCGAATCGATGGCCGTGCTCGAGCCGGTGGCCGACGGT TTTCGCAACTACCTGAAGGGCAAGTACCGGGTGCCCGCCGAGGTGCTGCTCGTCGACAAG GCGCAACTGCTGACGCTGAGCGCGCCGGAGATGACGGTGCTGCTGGGCGGCCTGCGCGTG CTGGGCGCGAACGTCGGGCAGAGCCGGCACGGCGTGTTCACCGCGCGCGAGCAGGCATTG ACCAACGACTTCTTCGTGAACCTGCTCGACATGGGCACCGAGTGGAAGCCGACGGCGGCC GACGCGGACGTGTTCGAAGGGCGCGACCGCGCGACGGGCGAGCTCAAGTGGACGGGCACG CGCGTCGATCTCGTGTTCGGCTCGCACTCGCAGTTGCGCGCGCTCGCGGAGGTCTACGGC AGCGCGGACGCGCAGGAGAAGTTCGTGCGCGACTTCGTCGCGGTCTGGAACAAGGTGATG AACCTCGACCGCTTCGATCTCGCGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q939D2 UniProtKB Entry Name KATG_BURPS GenBank Gene ID AY040244 PDB ID(s) 1MWV, 1X7U, 2B2O, 2B2Q, 2B2R, 2B2S, 2DV1, 2DV2, 2FXG, 2FXH, 2FXJ, 3N3N, 3N3O, 3N3P, 3N3Q, 3N3R, 3N3S, 4KA5, 4KA6, 4MVP, 4QZJ, 4QZL, 4QZP KEGG ID bps:BPSL2865 NCBI Gene ID 3092072 - General References
- Loprasert S, Sallabhan R, Whangsuk W, Mongkolsuk S: The Burkholderia pseudomallei oxyR gene: expression analysis and mutant characterization. Gene. 2002 Aug 21;296(1-2):161-9. [Article]
- Holden MT, Titball RW, Peacock SJ, Cerdeno-Tarraga AM, Atkins T, Crossman LC, Pitt T, Churcher C, Mungall K, Bentley SD, Sebaihia M, Thomson NR, Bason N, Beacham IR, Brooks K, Brown KA, Brown NF, Challis GL, Cherevach I, Chillingworth T, Cronin A, Crossett B, Davis P, DeShazer D, Feltwell T, Fraser A, Hance Z, Hauser H, Holroyd S, Jagels K, Keith KE, Maddison M, Moule S, Price C, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Simmonds M, Songsivilai S, Stevens K, Tumapa S, Vesaratchavest M, Whitehead S, Yeats C, Barrell BG, Oyston PC, Parkhill J: Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14240-5. Epub 2004 Sep 17. [Article]
- Donald LJ, Krokhin OV, Duckworth HW, Wiseman B, Deemagarn T, Singh R, Switala J, Carpena X, Fita I, Loewen PC: Characterization of the catalase-peroxidase KatG from Burkholderia pseudomallei by mass spectrometry. J Biol Chem. 2003 Sep 12;278(37):35687-92. Epub 2003 Jun 29. [Article]
- Singh R, Wiseman B, Deemagarn T, Donald LJ, Duckworth HW, Carpena X, Fita I, Loewen PC: Catalase-peroxidases (KatG) exhibit NADH oxidase activity. J Biol Chem. 2004 Oct 8;279(41):43098-106. Epub 2004 Jul 26. [Article]
- Jakopitsch C, Vlasits J, Wiseman B, Loewen PC, Obinger C: Redox intermediates in the catalase cycle of catalase-peroxidases from Synechocystis PCC 6803, Burkholderia pseudomallei, and Mycobacterium tuberculosis. Biochemistry. 2007 Feb 6;46(5):1183-93. [Article]
- Singh R, Wiseman B, Deemagarn T, Jha V, Switala J, Loewen PC: Comparative study of catalase-peroxidases (KatGs). Arch Biochem Biophys. 2008 Mar 15;471(2):207-14. doi: 10.1016/j.abb.2007.12.008. Epub 2007 Dec 23. [Article]
- Carpena X, Loprasert S, Mongkolsuk S, Switala J, Loewen PC, Fita I: Catalase-peroxidase KatG of Burkholderia pseudomallei at 1.7A resolution. J Mol Biol. 2003 Mar 21;327(2):475-89. [Article]
- Deemagarn T, Carpena X, Singh R, Wiseman B, Fita I, Loewen PC: Structural characterization of the Ser324Thr variant of the catalase-peroxidase (KatG) from Burkholderia pseudomallei. J Mol Biol. 2005 Jan 7;345(1):21-8. [Article]
- Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC: A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases. EMBO Rep. 2005 Dec;6(12):1156-62. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 1-hydroperoxy-L-tryptophan experimental unknown target Details