1-phosphatidylinositol phosphodiesterase

BE0002943ProteinListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)plcA

Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. It is acted on by 1 drug in DrugBank.

Gene name
plcA
UniProtKB entry
P34024Swiss-Prot
Cellular location
Secreted
Residues / weight
317 residues · 36,318 Da
Also known as
4.6.1.13 · Phosphatidylinositol diacylglycerol-lyase · Phosphatidylinositol-specific phospholipase C · PI-PLC · pic

Resolves to

Protein
UniProtP34024UniProt namePLC_LISMO
Gene
NCBI Gene987032
Pharmacology
KEGGlmo:lmo0201
Structure
PDB1AODPDB2PLC
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 1-phosphatidylinositol phosphodiesterase, and which indications are they being tested in?

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