Fatty acid metabolism regulator protein
Details
- Name
- Fatty acid metabolism regulator protein
- Kind
- protein
- Synonyms
- ysiA
- Gene Name
- fadR
- UniProtKB Entry
- P94548Swiss-Prot
- Organism
- Bacillus subtilis (strain 168)
- NCBI Taxonomy ID
- 224308
- Amino acid sequence
>lcl|BSEQ0012133|Fatty acid metabolism regulator protein MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIYLYFKNKEDILISLFKE KMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAIVTQLELRQSNLELRQKIN EILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTIDETVTTWVMNDQKYDLVALS NSVLELLVSGIHNK
- Number of residues
- 194
- Molecular Weight
- 21978.335
- Theoretical pI
- 6.53
- GO Classification
- FunctionsDNA bindingProcessesfatty acid metabolic process / lipid catabolic process / regulation of transcription, DNA-templated / transcription, DNA-templatedComponentscytoplasm
- General Function
- Transcriptional regulator in fatty acid degradation. Represses transcription of genes required for fatty acid transport and beta-oxidation, including acdA, fadA, fadB, fadE, fadF, fadG, fadH, fadM, fadN, lcfA and lcfB. Binding of FadR to DNA is specifically inhibited by long chain fatty acyl-CoA compounds of 14-20 carbon atoms in length.
- Specific Function
- DNA-binding transcription factor activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0012134|Fatty acid metabolism regulator protein (fadR) TTGAAGCAAAAACGGCCAAAGTATATGCAGATTATTGATGCAGCAGTAGAAGTCATTGCA GAAAACGGCTACCACCAGTCACAGGTATCCAAAATTGCCAAACAAGCCGGGGTAGCGGAC GGCACCATCTATCTCTATTTTAAAAACAAAGAAGATATTTTAATTTCTCTTTTCAAAGAA AAAATGGGTCAATTTATTGAGCGGATGGAAGAGGACATTAAAGAAAAAGCAACAGCGAAA GAGAAATTGGCGCTTGTGATTTCAAAGCATTTTTCCCTTTTAGCGGGTGACCATAATCTC GCCATTGTCACGCAGCTTGAGCTCCGCCAATCCAACTTGGAGCTGCGCCAAAAAATCAAC GAAATATTAAAAGGCTACTTAAATATTTTGGATGGCATTTTGACGGAAGGTATACAATCA GGCGAAATAAAAGAAGGCCTCGATGTCCGCCTCGCCCGGCAGATGATTTTTGGAACGATT GACGAAACTGTGACAACTTGGGTGATGAATGACCAAAAGTACGATCTCGTTGCGCTTTCA AACAGCGTTTTAGAATTATTGGTATCCGGAATTCACAATAAGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P94548 UniProtKB Entry Name FADR_BACSU GenBank Gene ID Z75208 PDB ID(s) 1VI0, 3WHB, 3WHC KEGG ID bsu:BSU28550 NCBI Gene ID 938105 - General References
- Wipat A, Carter N, Brignell SC, Guy BJ, Piper K, Sanders J, Emmerson PT, Harwood CR: The dnaB-pheA (256 degrees-240 degrees) region of the Bacillus subtilis chromosome containing genes responsible for stress responses, the utilization of plant cell walls and primary metabolism. Microbiology. 1996 Nov;142 ( Pt 11):3067-78. [Article]
- Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
- Matsuoka H, Hirooka K, Fujita Y: Organization and function of the YsiA regulon of Bacillus subtilis involved in fatty acid degradation. J Biol Chem. 2007 Feb 23;282(8):5180-94. Epub 2006 Dec 22. [Article]
- Ramos JL, Martinez-Bueno M, Molina-Henares AJ, Teran W, Watanabe K, Zhang X, Gallegos MT, Brennan R, Tobes R: The TetR family of transcriptional repressors. Microbiol Mol Biol Rev. 2005 Jun;69(2):326-56. [Article]
- Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ: Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins. 2005 Sep 1;60(4):787-96. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Dodecyl-Coa experimental unknown target Details