Type-4 uracil-DNA glycosylase

BE0003080ProteinThermus thermophilusudg

Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. It is acted on by 1 drug in DrugBank.

Gene name: udg
UniProtKB entry: Q5SKC5TrEMBL
Residues / weight: 205 residues · 22,966 Da
Also known as: 3.2.2.27 · TthUDG · TTUDGA · Uracil-DNA glycosylase

Resolves to

Protein

UniProtQ5SKC5UniProt nameUDGA_THET8

Gene

NCBI Gene3169183

Pharmacology

KEGGttj:TTHA0718

Structure

PDB1UI0PDB1UI1

Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action

2GO termsFunction, process and component, as structured annotations

1Pfam domainDomain architecture mapped to Pfam families and clans

1+ReferenceStructured and connected to the statements they support

Which compounds in development act on Type-4 uracil-DNA glycosylase, and which indications are they being tested in?

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