Pyrimidine-nucleoside phosphorylase

BE0003081ProteinGeobacillus stearothermophiluspdp

Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate. It is acted on by 1 drug in DrugBank.

Gene name
pdp
UniProtKB entry
P77836Swiss-Prot
Residues / weight
433 residues · 46,332 Da
Also known as
2.4.2.2 · pyn · PYNP

Resolves to

Protein
UniProtP77836UniProt namePDP_GEOSE
Structure
PDB1BRW
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Pyrimidine-nucleoside phosphorylase, and which indications are they being tested in?

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