ATP-dependent Clp protease ATP-binding subunit ClpX

BE0003089ProteinHelicobacter pylori (strain ATCC 700392 / 26695)clpX

ATP-dependent specificity component of the Clp protease. It is acted on by 1 drug in DrugBank.

Gene name: clpX
UniProtKB entry: O25926Swiss-Prot
Cellular location: Cytoplasmic
Residues / weight: 446 residues · 50,353 Da

Resolves to

Protein

UniProtO25926UniProt nameCLPX_HELPY

Gene

NCBI Gene900311

Pharmacology

KEGGheo:C694_07090

Structure

PDB1UM8

Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action

3GO termsFunction, process and component, as structured annotations

3Pfam domainsDomain architecture mapped to Pfam families and clans

3+ReferencesStructured and connected to the statements they support

Which approved drugs act on ATP-dependent Clp protease ATP-binding subunit ClpX, how selective are they, and which programs against it are still in active trials?

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