Glutamate decarboxylase alpha

BE0003129ProteinEscherichia coli (strain K12)gadA

Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. It is acted on by 1 drug in DrugBank.

Gene name
gadA
UniProtKB entry
P69908Swiss-Prot
Residues / weight
466 residues · 52,685 Da
Also known as
4.1.1.15 · GAD-alpha · gadS

Resolves to

Protein
UniProtP69908UniProt nameDCEA_ECOLI
Gene
NCBI Gene948027
Pharmacology
KEGGecj:JW3485
Structure
PDB1XEY
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Glutamate decarboxylase alpha, and which indications are they being tested in?

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