DUTPase

Details

Name
DUTPase
Kind
protein
Synonyms
  • EC 3.6.1.23
Gene Name
dut
UniProtKB Entry
Q0P8G4TrEMBL
Organism
Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
NCBI Taxonomy ID
192222
Amino acid sequence
>lcl|BSEQ0012194|DUTPase
MTNIEILENMLKLQQKLNDETNGLNWENGYTKEGKLISWRRCIYMECAELIDSFTWKHWK
NISSLTNWENVRIEIVDIWHFILSLLLEEYRDKNNKDFKAIATEVNAVSVFQDFCKEEEY
PNEGDIYGILNDIELIIHKCSGFGFNLGELLSTYFTLAIKCGLNLEILYKTYIGKNVLNI
FRQNNGYKDGSYKKTWNGKEDNEVLAQILEQELDFDTIYKKLEECYKKA
Number of residues
229
Molecular Weight
27021.56
Theoretical pI
4.68
GO Classification
Functions
dUTP diphosphatase activity / metal ion binding
General Function
Not Available
Specific Function
dUTP diphosphatase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012195|DUTPase (dut)
ATGACAAATATCGAAATTTTAGAAAATATGCTCAAACTCCAACAAAAACTCAACGATGAA
ACAAACGGCTTAAATTGGGAAAATGGCTACACCAAAGAAGGAAAACTGATCAGTTGGAGA
CGCTGTATTTATATGGAATGTGCAGAACTTATAGACTCTTTTACATGGAAACATTGGAAA
AATATTTCAAGTCTAACAAATTGGGAAAATGTGCGTATAGAGATTGTCGATATTTGGCAT
TTTATTTTAAGTCTTTTACTTGAAGAGTATCGCGATAAAAACAATAAAGATTTCAAAGCT
ATAGCCACAGAAGTTAATGCTGTAAGCGTGTTTCAAGATTTTTGCAAAGAAGAAGAATAC
CCTAATGAGGGTGATATTTATGGCATTTTAAATGATATAGAGCTTATTATCCATAAATGC
AGTGGTTTTGGATTTAATCTTGGAGAATTACTTTCAACCTATTTTACCCTAGCTATTAAA
TGTGGGCTAAATCTTGAAATTCTTTATAAGACCTACATAGGTAAAAATGTTTTAAATATT
TTTAGACAAAACAATGGTTACAAAGATGGCAGCTATAAAAAAACTTGGAATGGCAAAGAA
GACAATGAAGTTTTAGCTCAAATTTTAGAACAAGAGCTTGATTTTGATACTATTTATAAA
AAACTAGAAGAATGCTACAAAAAGGCATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ0P8G4
UniProtKB Entry NameQ0P8G4_CAMJE
GenBank Gene IDAL111168
PDB ID(s)1W2Y, 2CIC
KEGG IDcje:Cj1451
NCBI Gene ID905739
General References
  1. Parkhill J, Wren BW, Mungall K, Ketley JM, Churcher C, Basham D, Chillingworth T, Davies RM, Feltwell T, Holroyd S, Jagels K, Karlyshev AV, Moule S, Pallen MJ, Penn CW, Quail MA, Rajandream MA, Rutherford KM, van Vliet AH, Whitehead S, Barrell BG: The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature. 2000 Feb 10;403(6770):665-8. [Article]
  2. Moroz OV, Harkiolaki M, Galperin MY, Vagin AA, Gonzalez-Pacanowska D, Wilson KS: The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases. J Mol Biol. 2004 Oct 1;342(5):1583-97. [Article]
  3. Hemsworth GR, Moroz OV, Fogg MJ, Scott B, Bosch-Navarrete C, Gonzalez-Pacanowska D, Wilson KS: The crystal structure of the Leishmania major deoxyuridine triphosphate nucleotidohydrolase in complex with nucleotide analogues, dUMP, and deoxyuridine. J Biol Chem. 2011 May 6;286(18):16470-81. doi: 10.1074/jbc.M111.224873. Epub 2011 Mar 15. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2'-deoxyuridine 5'-alpha,beta-imido-diphosphateexperimentalunknowntargetDetails