Fiber

Details

Name
Fiber
Kind
protein
Synonyms
  • Fiber protein
Gene Name
L5
UniProtKB Entry
Q64823TrEMBL
Organism
Human adenovirus D37
NCBI Taxonomy ID
52275
Amino acid sequence
>lcl|BSEQ0022064|Fiber
MSKRLRVEDDFNPVYPYGYARNQNIPFLTPPFVSSDGFKNFPPGVLSLKLADPITITNGD
VSLKVGGGLTLQDGSLTVNPKAPLQVNTDKKLELAYDNPFESSANKLSLKVGHGLKVLDE
KSAAGLKDLIGKLVVLTGKGIGTENLENTDGSSRGIGINVRAREGLTFDNDGYLVAWNPK
YDTRTLWTTPDTSPNCTIAQDKDSKLTLVLTKCGSQILANVSLIVVAGKYHIINNKTNPK
IKSFTIKLLFNKNGVLLDNSNLGKAYWNFRSGNSNVSTAYEKAIGFMPNLVAYPKPSNSK
KYARDIVYGTIYLGGKPDQPAVIKTTFNQETGCEYSITFNFSWSKTYENVEFETTSFTFS
YIAQE
Number of residues
365
Molecular Weight
40092.19
Theoretical pI
9.35
GO Classification
Functions
metal ion binding
Processes
cell adhesion / pathogenesis / virion attachment to host cell
Components
viral capsid
General Function
Not Available
Specific Function
metal ion binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0006185|1098 bp
ATGTCAAAGAGGCTCCGGGTGGAAGATGACTTCAACCCCGTCTACCCCTATGGCTACGCG
CGGAATCAGAATATCCCCTTCCTCACTCCCCCCTTTGTCTCCTCCGATGGATTCAAAAAC
TTCCCCCCTGGGGTACTGTCACTCAAACTGGCTGATCCAATCACCATTACCAATGGGGAT
GTATCCCTCAAGGTGGGAGGTGGTCTCACTTTGCAAGATGGAAGCCTAACTGTAAACCCT
AAGGCTCCACTGCAAGTTAATACTGATAAAAAACTTGAGCTTGCATATGATAATCCATTT
GAAAGTAGTGCTAATAAACTTAGTTTAAAAGTAGGACATGGATTAAAAGTATTAGATGAA
AAAAGTGCTGCGGGGTTAAAAGATTTAATTGGCAAACTTGTGGTTTTAACAGGAAAAGGA
ATAGGCACTGAAAATTTAGAAAATACAGATGGTAGCAGCAGAGGAATTGGTATAAATGTA
AGAGCAAGAGAAGGGTTGACATTTGACAATGATGGATACTTGGTAGCATGGAACCCAAAG
TATGACACGCGCACACTTTGGACAACACCAGACACATCTCCAAACTGCACAATTGCTCAA
GATAAGGACTCTAAACTCACTTTGGTACTTACAAAGTGTGGAAGTCAAATATTAGCTAAT
GTGTCTTTGATTGTGGTCGCAGGAAAGTACCACATCATAAATAATAAGACAAATCCAAAA
ATAAAAAGTTTTACTATTAAACTGCTATTTAATAAGAACGGAGTGCTTTTAGACAACTCA
AATCTTGGAAAAGCTTATTGGAACTTTAGAAGTGGAAATTCCAATGTTTCGACAGCTTAT
GAAAAAGCAATTGGTTTTATGCCTAATTTGGTAGCGTATCCAAAACCCAGTAATTCTAAA
AAATATGCAAGAGACATAGTTTATGGAACTATATATCTTGGTGGAAAACCTGATCAGCCA
GCAGTCATTAAAACTACCTTTAACCAAGAAACTGGATGTGAATACTCTATCACATTTAAC
TTTAGTTGGTCCAAAACCTATGAAAATGTTGAATTTGAAACCACCTCTTTTACCTTCTCC
TATATTGCCCAAGAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ64823
UniProtKB Entry NameQ64823_9ADEN
GenBank Gene IDX94484
PDB ID(s)1UXA, 1UXE, 2WBW, 2WGT, 2WGU, 3N0I, 3QND, 4K6T, 4K6U, 4K6V, 4K6W, 4XQA, 4XQB
General References
  1. Burmeister WP, Guilligay D, Cusack S, Wadell G, Arnberg N: Crystal structure of species D adenovirus fiber knobs and their sialic acid binding sites. J Virol. 2004 Jul;78(14):7727-36. [Article]
  2. Johansson S, Nilsson E, Qian W, Guilligay D, Crepin T, Cusack S, Arnberg N, Elofsson M: Design, synthesis, and evaluation of N-acyl modified sialic acids as inhibitors of adenoviruses causing epidemic keratoconjunctivitis. J Med Chem. 2009 Jun 25;52(12):3666-78. doi: 10.1021/jm801609s. [Article]
  3. Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, Mennechet F, Schoehn G, Lortat-Jacob H, Dreja H, Ibanes S, Kalatzis V, Wang JP, Finberg RW, Cusack S, Kremer EJ: The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution. PLoS Pathog. 2009 Jan;5(1):e1000277. doi: 10.1371/journal.ppat.1000277. Epub 2009 Jan 2. [Article]
  4. Spjut S, Qian W, Bauer J, Storm R, Frangsmyr L, Stehle T, Arnberg N, Elofsson M: A potent trivalent sialic acid inhibitor of adenovirus type 37 infection of human corneal cells. Angew Chem Int Ed Engl. 2011 Jul 11;50(29):6519-21. doi: 10.1002/anie.201101559. Epub 2011 Jun 6. [Article]
  5. Nilsson EC, Storm RJ, Bauer J, Johansson SM, Lookene A, Angstrom J, Hedenstrom M, Eriksson TL, Frangsmyr L, Rinaldi S, Willison HJ, Pedrosa Domellof F, Stehle T, Arnberg N: The GD1a glycan is a cellular receptor for adenoviruses causing epidemic keratoconjunctivitis. Nat Med. 2011 Jan;17(1):105-9. doi: 10.1038/nm.2267. Epub 2010 Dec 12. [Article]
  6. Caraballo R, Saleeb M, Bauer J, Liaci AM, Chandra N, Storm RJ, Frangsmyr L, Qian W, Stehle T, Arnberg N, Elofsson M: Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells. Org Biomol Chem. 2015 Sep 21;13(35):9194-205. doi: 10.1039/c5ob01025j. Epub 2015 Jul 16. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
N-acetyl-alpha-neuraminic acidexperimentalunknowntargetDetails