Deoxycytidylate 5-hydroxymethyltransferase
Details
- Name
- Deoxycytidylate 5-hydroxymethyltransferase
- Kind
- protein
- Synonyms
- 2.1.2.8
- dCMP HMase
- dCMP hydroxymethylase
- Deoxycytidylate hydroxymethylase
- Gene Name
- 42
- UniProtKB Entry
- P08773Swiss-Prot
- Organism
- Enterobacteria phage T4
- NCBI Taxonomy ID
- 10665
- Amino acid sequence
>lcl|BSEQ0020666|Deoxycytidylate 5-hydroxymethyltransferase MISDSMTVEEIRLHLGLALKEKDFVVDKTGVKTIEIIGASFVADEPFIFGALNDEYIQRE LEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYGWAIWSEDNYAQYDMCLAELGQNP DSRRGIMIYTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDY AWQKYVLDKLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWKTGETHISKKD YVGKYA
- Number of residues
- 246
- Molecular Weight
- 28489.065
- Theoretical pI
- 6.04
- GO Classification
- Functionsdeoxycytidylate 5-hydroxymethyltransferase activity / thymidylate synthase activityProcessesdTMP biosynthetic process
- General Function
- Not Available
- Specific Function
- deoxycytidylate 5-hydroxymethyltransferase activity
- Pfam Domain Function
- Thymidylat_synt (PF00303)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0020667|Deoxycytidylate 5-hydroxymethyltransferase (42) ATGATTAGTGACTCTATGACAGTTGAAGAAATCCGTCTTCATTTGGGGCTTGCATTAAAA GAAAAAGATTTCGTAGTTGATAAAACAGGTGTTAAAACTATTGAAATTATTGGCGCATCA TTTGTAGCAGATGAACCGTTTATTTTTGGCGCTCTTAATGATGAATACATTCAGCGTGAA CTTGAATGGTATAAATCTAAAAGCTTGTTCGTTAAAGATATTCCGGGTGAAACACCGAAG ATTTGGCAACAAGTAGCATCTTCTAAAGGTGAAATTAACTCGAATTATGGTTGGGCTATC TGGTCAGAAGATAACTATGCTCAGTATGACATGTGTTTAGCTGAACTTGGTCAAAATCCT GATTCTCGACGTGGTATCATGATTTATACTCGTCCATCTATGCAGTTTGACTATAATAAA GATGGTATGTCAGATTTCATGTGCACGAATACAGTACAATACCTGATTCGTGACAAGAAA ATCAATGCGGTTGTTAACATGCGCTCAAATGACGTGGTCTTCGGATTCCGTAATGATTAT GCATGGCAAAAATACGTATTAGATAAATTAGTATCTGATTTGAATGCAGGTGATTCAACT CGCCAGTATAAAGCAGGTTCCATTATATGGAATGTTGGAAGCCTACATGTGTATTCTCGT CATTTTTATTTGGTTGATCATTGGTGGAAAACTGGCGAAACACATATTTCGAAAAAAGAT TATGTAGGAAAATACGCTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P08773 UniProtKB Entry Name DCHM_BPT4 GenBank Gene ID Y00148 PDB ID(s) 1B49, 1B5D, 1B5E KEGG ID vg:1258746 NCBI Gene ID 1258746 - General References
- Lamm N, Tomaschewski J, Ruger W: Nucleotide sequence of the deoxycytidylate hydroxymethylase gene of bacteriophage T4 (g42) and the homology of its gene product with thymidylate synthase of E. coli. Nucleic Acids Res. 1987 May 11;15(9):3920. [Article]
- Lamm N, Wang Y, Mathews CK, Ruger W: Deoxycytidylate hydroxymethylase gene of bacteriophage T4. Nucleotide sequence determination and over-expression of the gene. Eur J Biochem. 1988 Mar 15;172(3):553-63. [Article]
- Miller ES, Kutter E, Mosig G, Arisaka F, Kunisawa T, Ruger W: Bacteriophage T4 genome. Microbiol Mol Biol Rev. 2003 Mar;67(1):86-156, table of contents. [Article]
- Thylen C: Expression and DNA sequence of the cloned bacteriophage T4 dCMP hydroxymethylase gene. J Bacteriol. 1988 Apr;170(4):1994-8. [Article]
- Tomaschewski J, Gram H, Crabb JW, Ruger W: T4-induced alpha- and beta-glucosyltransferase: cloning of the genes and a comparison of their products based on sequencing data. Nucleic Acids Res. 1985 Nov 11;13(21):7551-68. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 2'-Deoxycytidine-5'-Monophosphate experimental unknown target Details