Cystathionine gamma-synthase

BE0003209ProteinEscherichia coli (strain K12)metB

Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. It is acted on by 2 drugs in DrugBank.

Gene name
metB
UniProtKB entry
P00935Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
386 residues · 41,550 Da
Also known as
2.5.1.48 · CGS · O-succinylhomoserine (thiol)-lyase

Resolves to

Protein
UniProtP00935UniProt nameMETB_ECOLI
Gene
NCBI Gene948434
Pharmacology
KEGGecj:JW3910
Structure
PDB1CS1
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cystathionine gamma-synthase, and which indications are they being tested in?

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