Tyrosine aminotransferase

Details

Name
Tyrosine aminotransferase
Kind
protein
Synonyms
  • 2.6.1.5
  • L-tyrosine:2-oxoglutarate aminotransferase
  • TAT
Gene Name
Not Available
UniProtKB Entry
P33447Swiss-Prot
Organism
Trypanosoma cruzi
NCBI Taxonomy ID
5693
Amino acid sequence
>lcl|BSEQ0012238|Tyrosine aminotransferase
MSSWDVSMSNHAGLVFNPIRTVSDNAKPSPSPKPIIKLSVGDPTLDKNLLTSAAQIKKLK
EAIDSQECNGYFPTVGSPEAREAVATWWRNSFVHKEELKSTIVKDNVVLCSGGSHGILMA
ITAICDAGDYALVPQPGFPHYETVCKAYGIGMHFYNCRPENDWEADLDEIRRLKDDKTKL
LIVTNPSNPCGSNFSRKHVEDIVRLAEELRLPLFSDEIYAGMVFKGKDPNATFTSVADFE
TTVPRVILGGTAKNLVVPGWRLGWLLYVDPHGNGPSFLEGLKRVGMLVCGPCTVVQAALG
EALLNTPQEHLDQIVAKIEESAMYLYNHIGECIGLAPTMPRGAMYLMSRIDLEKYRDIKT
DVEFFEKLLEEENVQVLPGTIFHAPGFTRLTTTRPVEVYREAVERIKAFCQRHAAV
Number of residues
416
Molecular Weight
46166.605
Theoretical pI
6.14
GO Classification
Functions
L-phenylalanine / L-tyrosine / pyridoxal phosphate binding
Processes
biosynthetic process / L-phenylalanine catabolic process / tyrosine catabolic process
Components
mitochondrion
General Function
Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate (By similarity).
Specific Function
L-tyrosine
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP33447
UniProtKB Entry NameATTY_TRYCR
PDB ID(s)1BW0
General References
  1. Bontempi EJ, Bua J, Aslund L, Porcel B, Segura EL, Henriksson J, Orn A, Pettersson U, Ruiz AM: Isolation and characterization of a gene from Trypanosoma cruzi encoding a 46-kilodalton protein with homology to human and rat tyrosine aminotransferase. Mol Biochem Parasitol. 1993 Jun;59(2):253-62. [Article]
  2. Montemartini M, Santome JA, Cazzulo JJ, Nowicki C: Purification and partial structural and kinetic characterization of tyrosine aminotransferase from epimastigotes of Trypanosoma cruzi. Biochem J. 1993 Jun 15;292 ( Pt 3):901-6. [Article]
  3. Blankenfeldt W, Nowicki C, Montemartini-Kalisz M, Kalisz HM, Hecht HJ: Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode. Protein Sci. 1999 Nov;8(11):2406-17. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
N(6)-(pyridoxal phosphate)-L-lysineexperimentalunknowntargetDetails