Thioredoxin

BE0003226ProteinAlicyclobacillus acidocaldariustrxA

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. It is acted on by 3 drugs in DrugBank.

Gene name
trxA
UniProtKB entry
P80579Swiss-Prot
Residues / weight
105 residues · 11,576 Da
Also known as
Trx

Resolves to

Protein
UniProtP80579UniProt nameTHIO_ALIAC
Structure
PDB1NSWPDB1NW2PDB1QUW
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Thioredoxin, how selective are they, and which programs against it are still in active trials?

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