DNA topoisomerase 4 subunit B

BE0003294ProteinEscherichia coli (strain K12)parE

Topoisomerase IV is essential for chromosome segregation; it is the principal protein responsible for decatenating newly replicated chromosomes (PubMed:9334322). It is acted on by 3 drugs in DrugBank.

Gene name
parE
UniProtKB entry
P20083Swiss-Prot
Cellular location
Cytoplasmic
Residues / weight
630 residues · 70,243 Da
Also known as
5.6.2.2 · 5.99.1.3 · nfxD · Topoisomerase IV subunit B

Resolves to

Protein
UniProtP20083UniProt namePARE_ECOLI
Gene
NCBI Gene947501
Pharmacology
KEGGecj:JW2998
Structure
PDB1S14PDB1S16PDB3FV5
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA topoisomerase 4 subunit B, and which indications are they being tested in?

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