Potassium-transporting ATPase ATP-binding subunit

BE0003296ProteinEscherichia coli (strain K12)kdpB

Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:23930894, PubMed:2849541, PubMed:8499455). It is acted on by 1 drug in DrugBank.

Gene name
kdpB
UniProtKB entry
P03960Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
682 residues · 72,198 Da
Also known as
3.6.3.12 · 7.2.2.6 · ATP phosphohydrolase [potassium-transporting] B chain · Potassium-binding and translocating subunit B · Potassium-translocating ATPase B chain

Resolves to

Protein
UniProtP03960UniProt nameKDPB_ECOLI
Gene
NCBI Gene947450
Pharmacology
KEGGecj:JW0685
Structure
PDB1SVJPDB1U7QPDB2A00
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Potassium-transporting ATPase ATP-binding subunit, and which indications are they being tested in?

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