Methionine synthase

BE0003310ProteinThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. It is acted on by 1 drug in DrugBank.

UniProtKB entry
Q9WYA5TrEMBL
Residues / weight
768 residues · 85,703 Da
Also known as
2.1.1.13 · 5-methyltetrahydrofolate S-homocysteine methyltransferase · 5-methyltetrahydrofolate--homocysteine methyltransferase

Resolves to

Protein
UniProtQ9WYA5UniProt nameQ9WYA5_THEMA
Gene
NCBI Gene897179
Pharmacology
KEGGtma:TM0268
Structure
PDB1Q7MPDB1Q7QPDB1Q7Z
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Methionine synthase, and which indications are they being tested in?

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