Devancosaminyl-vancomycin vancosaminetransferase

BE0003321ProteinAmycolatopsis orientalisgtfD

Catalyzes the attachment of L-vancosamine to a monoglucosylated heptapeptide intermediate during the final stage of glycopeptide antibiotic vancomycin biosynthesis. It is acted on by 1 drug in DrugBank.

Gene name
gtfD
UniProtKB entry
Q9AFC7Swiss-Prot
Residues / weight
408 residues · 42,881 Da
Also known as
2.4.1.322 · Desvancosamine-vancomycin TDP-vancosaminyltransferase · Desvancosaminyl-vancomycin vancosaminetransferase · Devancosamine-vancomycin TDP-vancosaminyltransferase · Glycosyltransferase GtfD

Resolves to

Protein
UniProtQ9AFC7UniProt nameGTFD_AMYOR
Structure
PDB1RRV
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Devancosaminyl-vancomycin vancosaminetransferase, and which indications are they being tested in?

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