3-hydroxyanthranilate 3,4-dioxygenase

Details

Name
3-hydroxyanthranilate 3,4-dioxygenase
Kind
protein
Synonyms
  • 1.13.11.6
  • 3-HAO
  • 3-hydroxyanthranilate oxygenase
  • 3-hydroxyanthranilic acid dioxygenase
  • HAD
Gene Name
nbaC
UniProtKB Entry
Q1LCS4Swiss-Prot
Organism
Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507 / CH34)
NCBI Taxonomy ID
266264
Amino acid sequence
>lcl|BSEQ0017064|3-hydroxyanthranilate 3,4-dioxygenase
MLTYGAPFNFPRWIDEHAHLLKPPVGNRQVWQDSDFIVTVVGGPNHRTDYHDDPLEEFFY
QLRGNAYLNLWVDGRRERADLKEGDIFLLPPHVRHSPQRPEAGSACLVIERQRPAGMLDG
FEWYCDACGHLVHRVEVQLKSIVTDLPPLFESFYASEDKRRCPHCGQVHPGRAA
Number of residues
174
Molecular Weight
20027.475
Theoretical pI
6.5
GO Classification
Functions
3-hydroxyanthranilate 3,4-dioxygenase activity / iron ion binding
Processes
NAD biosynthetic process
General Function
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Specific Function
3-hydroxyanthranilate 3,4-dioxygenase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017065|3-hydroxyanthranilate 3,4-dioxygenase (nbaC)
ATGCTGACCTACGGAGCGCCCTTCAATTTCCCGCGCTGGATCGACGAGCATGCACACCTG
TTGAAGCCGCCCGTCGGCAACCGGCAGGTGTGGCAGGACAGCGATTTCATCGTGACGGTG
GTGGGCGGGCCCAACCACCGCACGGATTATCACGACGATCCGCTCGAGGAATTTTTCTAC
CAGCTGCGCGGCAATGCCTACCTGAATCTCTGGGTCGACGGCAGGCGCGAGCGGGCGGAC
CTGAAAGAGGGTGACATCTTCCTGCTGCCCCCGCACGTTCGCCATTCCCCGCAGCGTCCC
GAGGCCGGCAGCGCCTGCCTGGTGATCGAGCGGCAGCGGCCCGCCGGTATGCTGGACGGA
TTCGAGTGGTATTGCGATGCATGCGGTCACCTGGTGCATCGCGTCGAGGTGCAGCTCAAG
AGCATCGTCACCGACCTCCCGCCTCTTTTCGAGAGCTTCTACGCCTCGGAAGACAAGCGC
CGCTGCCCGCACTGCGGACAGGTCCATCCCGGACGCGCGGCCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ1LCS4
UniProtKB Entry Name3HAO_CUPMC
GenBank Gene IDCP000353
PDB ID(s)1YFU, 1YFW, 1YFX, 1YFY, 4HSJ, 4HSL, 4HVO, 4HVQ, 4HVR, 4I3P, 4L2N
KEGG IDrme:Rmet_5193
NCBI Gene ID24153212
General References
  1. Colabroy KL, Zhai H, Li T, Ge Y, Zhang Y, Liu A, Ealick SE, McLafferty FW, Begley TP: The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry. 2005 May 31;44(21):7623-31. [Article]
  2. Zhang Y, Colabroy KL, Begley TP, Ealick SE: Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis. Biochemistry. 2005 May 31;44(21):7632-43. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
2-AMINO-4-CHLORO-3-HYDROXYBENZOIC ACIDexperimentalunknowntargetDetails