3-hydroxyanthranilate 3,4-dioxygenase

BE0003333ProteinRalstonia metallidurans (strain CH34 / ATCC 43123 / DSM 2839)nbaC

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. It is acted on by 1 drug in DrugBank.

Gene name
nbaC
UniProtKB entry
Q1LCS4Swiss-Prot
Residues / weight
174 residues · 20,027 Da
Also known as
1.13.11.6 · 3-HAO · 3-hydroxyanthranilate oxygenase · 3-hydroxyanthranilic acid dioxygenase · HAD

Resolves to

Protein
UniProtQ1LCS4UniProt name3HAO_CUPMC
Gene
NCBI Gene24153212
Pharmacology
KEGGrme:Rmet_5193
Structure
PDB1YFUPDB1YFWPDB1YFX
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on 3-hydroxyanthranilate 3,4-dioxygenase, and which indications are they being tested in?

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