Aspartate carbamoyltransferase catalytic subunit

BE0003341ProteinEscherichia coli (strain K12)pyrB

Catalyzes the condensation of carbamoyl phosphate and aspartate to form carbamoyl aspartate and inorganic phosphate, the committed step in the de novo pyrimidine nucleotide biosynthesis pathway. It is acted on by 1 drug in DrugBank.

Gene name
pyrB
UniProtKB entry
P0A786Swiss-Prot
Residues / weight
311 residues · 34,427 Da
Also known as
2.1.3.2 · Aspartate transcarbamylase · ATCase

Resolves to

Protein
UniProtP0A786UniProt namePYRB_ECOLI
Gene
NCBI Gene948767
Pharmacology
KEGGecj:JW4204
Structure
PDB1ACMPDB1AT1PDB1D09
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Aspartate carbamoyltransferase catalytic subunit, and which indications are they being tested in?

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