Succinate dehydrogenase flavoprotein subunit

BE0003342ProteinEscherichia coli (strain K12)sdhA

Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth. It is acted on by 3 drugs in DrugBank.

Gene name
sdhA
UniProtKB entry
P0AC41Swiss-Prot
Cellular location
Cell inner membrane
Residues / weight
588 residues · 64,421 Da
Also known as
1.3.5.1

Resolves to

Protein
UniProtP0AC41UniProt nameSDHA_ECOLI
Gene
NCBI Gene945402
Pharmacology
KEGGecj:JW0713
Structure
PDB1NEKPDB1NENPDB2ACZ
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Succinate dehydrogenase flavoprotein subunit, and which indications are they being tested in?

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