Bifunctional ligase/repressor BirA

BE0003345ProteinEscherichia coli (strain K12)birA

Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. It is acted on by 1 drug in DrugBank.

Gene name
birA
UniProtKB entry
P06709Swiss-Prot
Residues / weight
321 residues · 35,312 Da
Also known as
bioR · Biotin operon repressor · Biotin--[acetyl-CoA-carboxylase] ligase · Biotin--protein ligase · Biotin-[acetyl-CoA carboxylase] synthetase

Resolves to

Protein
UniProtP06709UniProt nameBIRA_ECOLI
Gene
NCBI Gene948469
Pharmacology
KEGGecj:JW3941
Structure
PDB1BIAPDB1BIBPDB1HXD
Drugs

What you can answer from here — as of September 04, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
16+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Bifunctional ligase/repressor BirA, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In