Calpain-1 catalytic subunit

BE0003346ProteinHumansCAPN1

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:19617626, PubMed:21531719, PubMed:2400579). It is acted on by 4 drugs in DrugBank.

Gene name
CAPN1
UniProtKB entry
P07384Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
714 residues · 81,889 Da
Also known as
3.4.22.52 · Calcium-activated neutral proteinase 1 · Calpain mu-type · Calpain-1 large subunit · CANP 1

Resolves to

Protein
UniProtP07384UniProt nameCAN1_HUMAN
Gene
HGNCHGNC:1476NCBI Gene823GeneCardsCAPN1
Pharmacology
IUPHAR/GtoPdb2336KEGGhsa:823
Structure
PDB1ZCMPDB2ARYPDB7W7O
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calpain-1 catalytic subunit, how selective are they, and which programs against it are still in active trials?

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