Deoxyuridine 5'-triphosphate nucleotidohydrolase

BE0003348ProteinPlasmodium falciparum (isolate 3D7)

Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. It is acted on by 1 drug in DrugBank.

UniProtKB entry
Q8II92TrEMBL
Residues / weight
173 residues · 19,573 Da
Also known as
3.6.1.23 · Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative · dUTP pyrophosphatase · dUTPase

Resolves to

Protein
UniProtQ8II92UniProt nameQ8II92_PLAF7
Gene
NCBI Gene810829
Pharmacology
KEGGpfa:PF11_0282
Structure
PDB1VYQPDB2Y8CPDB3T60
Drugs

What you can answer from here — as of May 03, 2025

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Deoxyuridine 5'-triphosphate nucleotidohydrolase, and which indications are they being tested in?

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