Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative
Details
- Name
- Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- Not Available
- UniProtKB Entry
- Q8II92TrEMBL
- Organism
- Plasmodium falciparum (isolate 3D7)
- NCBI Taxonomy ID
- 36329
- Amino acid sequence
>lcl|BSEQ0012343|Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative MHLKIVCLSDEVREMYKNHKTHHEGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKS NYYYKCEKSENKKKDDDKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAAL DNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGSTSNNKY
- Number of residues
- 173
- Molecular Weight
- 19572.98
- Theoretical pI
- 7.06
- GO Classification
- FunctionsdUTP diphosphatase activityProcessesDNA replication / dUTP metabolic process / tRNA metabolic process
- General Function
- Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
- Specific Function
- dUTP diphosphatase activity
- Pfam Domain Function
- Not Available
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0012344|Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative ATGCATTTAAAAATTGTATGTCTGAGTGATGAGGTCAGAGAAATGTACAAGAATCATAAA ACACATCATGAAGGTGATAGTGGATTAGATTTGTTTATTGTAAAAGATGAAGTACTGAAG CCAAAGTCCACAACTTTTGTTAAGCTTGGAATTAAGGCAATAGCATTACAATATAAATCT AATTATTATTATAAATGTGAAAAATCGGAAAATAAAAAAAAAGATGATGACAAATCCAAT ATTGTAAATACGAGCTTTTTATTATTTCCTCGTAGCAGTATATCCAAAACCCCATTACGC TTAGCTAATTCAATTGGACTAATTGATGCAGGTTATAGAGGAGAAATTATTGCCGCCTTG GATAATACTAGTGACCAAGAGTATCACATTAAAAAAAATGATAAATTAGTACAATTGGTC TCTTTTACAGGGGAACCACTTTCTTTTGAATTAGTTGAGGAACTGGATGAAACTTCCAGA GGAGAAGGAGGTTTTGGATCGACATCGAATAATAAATATTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8II92 UniProtKB Entry Name Q8II92_PLAF7 GenBank Gene ID AE014840 PDB ID(s) 1VYQ, 2Y8C, 3T60, 3T64, 3T6Y, 3T70 KEGG ID pfa:PF11_0282 NCBI Gene ID 810829 - General References
- Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B: Genome sequence of the human malaria parasite Plasmodium falciparum. Nature. 2002 Oct 3;419(6906):498-511. [Article]
- Whittingham JL, Leal I, Nguyen C, Kasinathan G, Bell E, Jones AF, Berry C, Benito A, Turkenburg JP, Dodson EJ, Ruiz Perez LM, Wilkinson AJ, Johansson NG, Brun R, Gilbert IH, Gonzalez Pacanowska D, Wilson KS: dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors. Structure. 2005 Feb;13(2):329-38. [Article]
- Baragana B, McCarthy O, Sanchez P, Bosch-Navarrete C, Kaiser M, Brun R, Whittingham JL, Roberts SM, Zhou XX, Wilson KS, Johansson NG, Gonzalez-Pacanowska D, Gilbert IH: beta-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase. Bioorg Med Chem. 2011 Apr 1;19(7):2378-91. doi: 10.1016/j.bmc.2011.02.012. Epub 2011 Feb 17. [Article]
- Hampton SE, Baragana B, Schipani A, Bosch-Navarrete C, Musso-Buendia JA, Recio E, Kaiser M, Whittingham JL, Roberts SM, Shevtsov M, Brannigan JA, Kahnberg P, Brun R, Wilson KS, Gonzalez-Pacanowska D, Johansson NG, Gilbert IH: Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase. ChemMedChem. 2011 Oct 4;6(10):1816-31. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 1-{(2S,5S)-4-FLUORO-5-[(TRITYLOXY)METHYL]TETRAHYDROFURAN-2-YL}PYRIMIDINE-2,4(1H,3H)-DIONE experimental unknown target Details