Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

BE0003350ProteinEscherichia coli (strain K12)ispU

Generates ditrans,octacis-undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) and farnesyl diphosphate (FPP). It is acted on by 7 drugs in DrugBank.

Gene name
ispU
UniProtKB entry
P60472Swiss-Prot
Residues / weight
253 residues · 28,444 Da
Also known as
2.5.1.31 · Ditrans,polycis-undecaprenylcistransferase · rth · UDS · Undecaprenyl diphosphate synthase

Resolves to

Protein
UniProtP60472UniProt nameUPPS_ECOLI
Gene
NCBI Gene944874
Pharmacology
KEGGecj:JW0169
Structure
PDB1JP3PDB1UEHPDB1V7U
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), and which indications are they being tested in?

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