NAD-dependent protein deacylase sirtuin-5, mitochondrial

BE0003362ProteinHumansSIRT5

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469). It is acted on by 5 drugs in DrugBank.

Gene name
SIRT5
UniProtKB entry
Q9NXA8Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
310 residues · 33,881 Da
Also known as
2.3.1.- · Regulatory protein SIR2 homolog 5 · SIR2-like protein 5 · SIR2L5

Resolves to

Protein
UniProtQ9NXA8UniProt nameSIR5_HUMAN
Gene
HGNCHGNC:14933NCBI Gene23408GeneCardsSIRT5
Pharmacology
IUPHAR/GtoPdb2711KEGGhsa:23408
Structure
PDB2B4YPDB2NYRPDB3RIG
Drugs

What you can answer from here — as of September 07, 2019

5DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which approved drugs act on NAD-dependent protein deacylase sirtuin-5, mitochondrial, how selective are they, and which programs against it are still in active trials?

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