RNA polymerase sigma factor SigA

BE0003370ProteinThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)sigA

Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. It is acted on by 2 drugs in DrugBank.

Gene name: sigA
UniProtKB entry: Q5SKW1TrEMBL
Cellular location: Cytoplasm
Residues / weight: 423 residues · 48,524 Da
Also known as: RpoD

Resolves to

Protein

UniProtQ5SKW1UniProt nameQ5SKW1_THET8

Gene

NCBI Gene3169450

Pharmacology

KEGGttj:TTHA0532

Structure

PDB1ZYRPDB2A68PDB2A69

Drugs

What you can answer from here — as of September 04, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action

6GO termsFunction, process and component, as structured annotations

4Pfam domainsDomain architecture mapped to Pfam families and clans

12+ReferencesStructured and connected to the statements they support

Which compounds in development act on RNA polymerase sigma factor SigA, and which indications are they being tested in?

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