Metalloproteinase inhibitor 3

BE0003371ProteinHumansTIMP3

Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs). It is acted on by 1 drug in DrugBank.

Gene name
TIMP3
UniProtKB entry
P35625Swiss-Prot
Cellular location
Secreted, extracellular space, extracellular matrix
Residues / weight
211 residues · 24,145 Da
Also known as
Protein MIG-5 · TIMP-3 · Tissue inhibitor of metalloproteinases 3

Resolves to

Protein
UniProtP35625UniProt nameTIMP3_HUMAN
Gene
HGNCHGNC:11822NCBI Gene7078GeneCardsTIMP3
Pharmacology
KEGGhsa:7078
Structure
PDB3CKI
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
20+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Metalloproteinase inhibitor 3, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In