E3 ubiquitin-protein transferase MAEA

BE0003374ProteinHumansMAEA

Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. It is acted on by 1 drug in DrugBank.

Gene name
MAEA
UniProtKB entry
Q7L5Y9Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
396 residues · 45,287 Da
Also known as
2.3.2.27 · Cell proliferation-inducing gene 5 protein · EMP · Erythroblast macrophage protein · HLC-10

Resolves to

Protein
UniProtQ7L5Y9UniProt nameMAEA_HUMAN
Gene
HGNCHGNC:13731NCBI Gene10296GeneCardsMAEA
Pharmacology
KEGGhsa:10296
Structure
PDB8PJN
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
7GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on E3 ubiquitin-protein transferase MAEA, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In