Scavenger receptor cysteine-rich type 1 protein M130

BE0003375ProteinHumansCD163

Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. It is acted on by 1 drug in DrugBank.

Gene name
CD163
UniProtKB entry
Q86VB7Swiss-Prot
Cellular location
Secreted
Residues / weight
1,156 residues · 125,450 Da
Also known as
Hemoglobin scavenger receptor · M130

Resolves to

Protein
UniProtQ86VB7UniProt nameC163A_HUMAN
Gene
HGNCHGNC:1631NCBI Gene9332GeneCardsCD163
Pharmacology
KEGGhsa:9332
Structure
PDB8XMKPDB8XMPPDB8XMQ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Scavenger receptor cysteine-rich type 1 protein M130, how selective are they, and which programs against it are still in active trials?

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