Interleukin-23 subunit alpha

BE0003415ProteinHumansIL23A

Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity (PubMed:11114383). It is acted on by 6 drugs in DrugBank.

Gene name
IL23A
UniProtKB entry
Q9NPF7Swiss-Prot
Cellular location
Secreted
Residues / weight
189 residues · 20,730 Da
Also known as
IL-23 subunit alpha · IL-23-A · IL-23p19 · Interleukin-23 subunit p19 · SGRF

Resolves to

Protein
UniProtQ9NPF7UniProt nameIL23A_HUMAN
Gene
HGNCHGNC:15488NCBI Gene51561GeneCardsIL23A
Pharmacology
KEGGhsa:51561
Structure
PDB3D85PDB3D87PDB3DUH
Drugs

What you can answer from here — as of September 07, 2019

6DrugsApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Interleukin-23 subunit alpha, how selective are they, and which programs against it are still in active trials?

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