cAMP-dependent protein kinase type II-alpha regulatory subunit

BE0003424ProteinHumansPRKAR2A

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. It is acted on by 1 drug in DrugBank.

Gene name
PRKAR2A
UniProtKB entry
P13861Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
404 residues · 45,518 Da
Also known as
PKR2 · PRKAR2

Resolves to

Protein
UniProtP13861UniProt nameKAP2_HUMAN
Gene
HGNCHGNC:9391NCBI Gene5576GeneCardsPRKAR2A
Pharmacology
IUPHAR/GtoPdb1474KEGGhsa:5576
Structure
PDB2IZXPDB2KYGPDB4ZP3
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which compounds in development act on cAMP-dependent protein kinase type II-alpha regulatory subunit, and which indications are they being tested in?

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