Centromere-associated protein E

BE0003434ProteinHumansCENPE

Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. It is acted on by 1 drug in DrugBank.

Gene name
CENPE
UniProtKB entry
Q02224Swiss-Prot
Cellular location
Chromosome, centromere, kinetochore
Residues / weight
2,701 residues · 316,413 Da
Also known as
CENP-E · Centromere protein E · Kinesin-7 · Kinesin-related protein CENPE

Resolves to

Protein
UniProtQ02224UniProt nameCENPE_HUMAN
Gene
HGNCHGNC:1856NCBI Gene1062GeneCardsCENPE
Pharmacology
KEGGhsa:1062
Structure
PDB1T5CPDB5JVPPDB6M4I
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
9GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
17+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Centromere-associated protein E, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In