Gag polyprotein
Details
- Name
- Gag polyprotein
- Kind
- protein
- Synonyms
- Pr55Gag
- Gene Name
- gag
- UniProtKB Entry
- O93182Swiss-Prot
- Organism
- HIV-1
- NCBI Taxonomy ID
- 388826
- Amino acid sequence
>lcl|BSEQ0006705|Gag polyprotein MGARASVLSGGKLDAWEKIRLRPGGKKKYRLKHLVWASRELERFALNPGLLETPEGCLQI IEQIQPAIKTGTEELKSLFNLVAVLYCVHRKIDVKDTKEALDKIEEIQNKSQQKTQQAAA DKEKDNKVSQNYPIVQNAQGQMVHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGAT PQDLNAMLNTVGGHQAAMQMLKDTINEEAAEWDRVHPVHAGPIPPGQMREPRGSDIAGTT STLQEQIAWMTGNPAIPVGDIYKRWIILGLNKIVRMYSPVSILDIKQGPKEPFRDYVDRF FKTLRAEQATQDVKNWMTETLLVQNANPDCKTILRALGQGASIEEMMTACQGVGGPSHKA RVLAEAMSQVTNTNTAIMMQKGNFKGQRKFVKCFNCGKEGHIARNCRAPRKKGCWKCGRE GHQMKDCTERQANFLGKIWPSSKGRPGNFLQSRPEPTAPPAESFGFGEEMTPSPKQEQLK DKEPPLASLRSLFGSDPLLQ
- Number of residues
- 500
- Molecular Weight
- 55673.715
- Theoretical pI
- 9.59
- GO Classification
- FunctionsRNA binding / structural molecule activity / zinc ion bindingProcessesviral budding via host ESCRT complex / viral release from host cellComponentshost cell nucleus / host cell plasma membrane / host multivesicular body / viral nucleocapsid / virion membrane
- General Function
- Gag polyprotein Mediates, with Gag-Pol polyprotein, the essential events in virion assembly, including binding the plasma membrane, making the protein-protein interactions necessary to create spherical particles, recruiting the viral Env proteins, and packaging the genomic RNA via direct interactions with the RNA packaging sequence (Psi).
- Specific Function
- RNA binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Host cell membrane
- Gene sequence
>lcl|BSEQ0006704|1503 bp ATGGGTGCGAGAGCGTCAGTATTAAGCGGCGGAAAATTAGATGCTTGGGAGAAAATTCGG CTAAGGCCAGGGGGAAAGAAAAAATATAGGCTAAAACATCTAGTATGGGCAAGCAGGGAG CTGGAAAGATTTGCACTTAACCCCGGCCTTTTAGAAACACCAGAAGGCTGTCTACAGATA ATAGAACAGATACAGCCAGCTATTAAGACAGGAACAGAAGAACTTAAATCATTATTTAAT CTAGTAGCAGTCCTCTATTGCGTACATCGAAAAATAGATGTGAAAGACACCAAGGAGGCT TTAGATAAGATAGAGGAAATACAAAACAAAAGTCAGCAAAAAACACAGCAAGCAGCAGCT GATAAGGAAAAAGACAACAAGGTCAGTCAAAATTATCCTATAGTACAGAATGCTCAAGGG CAGATGGTACACCAGGCCATATCACCTAGGACCTTAAATGCATGGGTAAAAGTAGTAGAA GAAAAGGCTTTTAGCCCAGAAGTAATACCCATGTTTTCAGCATTATCAGAAGGAGCCACC CCACAAGACTTAAATGCTATGCTAAATACAGTGGGGGGACATCAAGCAGCCATGCAGATG TTAAAAGATACAATCAATGAGGAAGCTGCAGAATGGGACAGGGTACATCCAGTGCATGCA GGGCCTATTCCACCAGGCCAAATGAGAGAACCAAGGGGAAGCGATATAGCAGGAACTACT AGTACCCTGCAGGAACAAATAGCATGGATGACAGGCAATCCAGCTATCCCAGTGGGAGAC ATCTATAAAAGATGGATAATCCTGGGATTAAATAAGATAGTAAGAATGTATAGTCCTGTC AGCATTCTGGACATAAAACAAGGGCCAAAAGAACCCTTTAGAGACTATGTAGACAGGTTT TTTAAAACTTTAAGAGCTGAGCAAGCCACACAGGATGTGAAGAATTGGATGACAGAAACC TTGTTGGTCCAAAATGCAAATCCAGATTGCAAGACTATATTAAGAGCATTAGGACAAGGG GCTTCAATAGAAGAAATGATGACAGCATGTCAGGGAGTGGGAGGACCTAGTCATAAAGCA AGAGTTTTGGCTGAGGCAATGAGCCAAGTAACAAATACAAATACAGCCATAATGATGCAG AAAGGCAACTTTAAGGGCCAAAGAAAATTTGTTAAATGCTTCAACTGTGGCAAAGAGGGA CACATAGCCAGAAATTGCAGGGCCCCTAGGAAAAAGGGCTGTTGGAAATGTGGAAGAGAA GGACATCAGATGAAAGACTGCACAGAGAGACAGGCTAATTTTTTAGGGAAAATTTGGCCT TCCAGCAAAGGGAGGCCAGGAAATTTTCTCCAGAGCAGGCCAGAACCAACAGCCCCACCA GCAGAGAGCTTCGGGTTCGGAGAGGAGATGACCCCCTCTCCGAAGCAGGAGCAGCTGAAG GACAAGGAACCTCCCTTAGCTTCCCTCAGATCACTCTTTGGCAGCGACCCCTTGTTACAG TAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O93182 UniProtKB Entry Name GAG_HV190 GenBank Gene ID AF005496 - General References
- Gao F, Robertson DL, Carruthers CD, Morrison SG, Jian B, Chen Y, Barre-Sinoussi F, Girard M, Srinivasan A, Abimiku AG, Shaw GM, Sharp PM, Hahn BH: A comprehensive panel of near-full-length clones and reference sequences for non-subtype B isolates of human immunodeficiency virus type 1. J Virol. 1998 Jul;72(7):5680-98. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details PA-1050040 investigational unknown target Details